In aesthetic medicine, few innovations have sparked as much buzz in recent years as polynucleotide face injections. Once reserved for regenerative skin support in post-surgical or medical cases, these powerful injectables are now making waves in mainstream aesthetics — and they’re being hailed by many as the next evolution beyond traditional dermal fillers.
So, what’s behind the growing popularity of polynucleotides? And are they actually replacing dermal fillers, or simply offering a new kind of result?
At Mesglo Aesthetic Clinic London, we’re at the forefront of this shift, blending regenerative injectables with precision aesthetic design. In this article, we break down what makes polynucleotides different, when to use them instead of fillers, and how they’re transforming modern facial rejuvenation.
A Personal Note from the Mesglo Team
This question — “Are polynucleotides replacing fillers?” — is one we’ve been asked more and more in recent months. And to be honest, we’re not surprised. Today’s aesthetic client isn’t looking for extremes — they’re looking for balance, subtlety, and real skin health. They want that glow that makes people say, “You look amazing,” without guessing what was done.
At Mesglo, we’ve seen polynucleotides change the game for so many of our clients. These aren’t just cosmetic treatments — they’re cellular rejuvenation therapies. Whether someone’s just beginning their skin journey or they’ve tried filler and want a more natural alternative, polynucleotides offer something unique: the ability to rebuild and regenerate — not just temporarily enhance.
But that doesn’t mean fillers are “out.” We still use dermal fillers every day at Mesglo — especially when it comes to facial contouring, deep support, and structural volume loss. What’s changing is the mindset. We’re using fillers more strategically, in smaller quantities, and pairing them with treatments like polynucleotides to get a smoother, longer-lasting, and far more natural result.
We created this guide to help you understand the difference — and to help you make decisions based not just on trends, but on what your skin actually needs. Because the best treatment plan is always one that’s informed, personalised, and focused on you.
We’re proud to be a clinic that offers both — and we’ll always help you choose with honesty, not hype.
Warmly,
The Mesglo Aesthetic Clinic Team
What Are Polynucleotide Injections?
Polynucleotides are chains of natural DNA fragments that stimulate the skin’s own regeneration process. When injected, they:
- Activate fibroblasts to produce collagen and elastin
- Improve tissue oxygenation and microcirculation
- Repair skin damaged by sun, ageing, or inflammation
- Increase hydration and elasticity
Unlike dermal fillers, which are designed to add volume immediately by placing hyaluronic acid beneath the skin, polynucleotides work gradually by improving the health and structure of your skin over time.
✅ Learn more about Polynucleotide Injections at Mesglo
Fillers vs. Polynucleotides: What’s the Difference?
| Feature | Dermal Fillers | Polynucleotide Injections |
|---|---|---|
| Primary Purpose | Restore volume and shape | Regenerate and strengthen skin |
| Main Ingredient | Hyaluronic acid | DNA-derived polynucleotides |
| Speed of Results | Immediate | Gradual (2–6 weeks) |
| Longevity | 6–12 months | Up to 6 months, with long-term benefits |
| Risk of Puffiness | Possible, especially under eyes | None |
| Skin Quality Impact | Limited | High – collagen, hydration, resilience |
| Best For | Shape, lift, contour | Texture, tone, firmness |
Why Clients Are Switching
Clients in 2025 are more informed, more natural-focused, and more interested in skin health over structure. Many are asking:
“Can I get the glow and firmness without the filler look?”
Polynucleotides answer that with a resounding yes.
They’re ideal for:
- Clients with mild to moderate ageing who don’t need volume yet
- Those who want more skin quality, not just shape
- People who have had fillers and now want to switch to a subtler, regenerative method
Can Polynucleotides Replace Fillers Completely?
In some cases, yes. In others, they’re better as a complementary treatment.
When to use polynucleotides instead of fillers:
- Early signs of skin laxity
- Creepiness or dullness without volume loss
- Under-eye rejuvenation (avoids puffiness and Tyndall effect)
🔗 Explore Lumi Eyes – a polynucleotide under-eye solution
When to combine them:
- You want both volume and skin regeneration
- You’ve had fillers before and want to support skin integrity
- You’re spacing out your filler use but still want visible improvements
At Mesglo, we often recommend a polynucleotide course first to improve skin health, followed by targeted, conservative filler placement only where truly needed.
What Is the Treatment Like?
A typical session includes:
- Consultation and skin assessment
- Cleansing and numbing
- Multiple microinjections using a fine needle or cannula
- Aftercare: avoid sun, makeup, and intense activity for 24–48 hours
Treatment takes 20–30 minutes and has minimal downtime — some redness or swelling is normal for a day or two.
We usually recommend a course of 3 sessions, spaced 2–3 weeks apart, for optimal results.
Final Thoughts: Evolution, Not Replacement
Polynucleotides aren’t here to replace fillers — they’re here to change the way we think about injectables.
Instead of just filling lines or lifting cheeks, we’re now able to stimulate your skin to heal, strengthen, and glow on its own terms.
It’s not about choosing one or the other — it’s about using each tool wisely. And at Mesglo, that’s what we do best.
📍 Mesglo Aesthetic Clinic London
Unit 4, 10 Portman Square
London W1H 6AZ
🌍 mesglolondon.co.uk
📅 Book your consultation and discover the best injectable for your face, your skin, and your future.