In the ever-evolving world of aesthetics and regenerative skincare, one molecule is taking the industry by storm: polynucleotides. Known for their remarkable ability to repair, regenerate, and restore the skin at a cellular level, polynucleotides are quickly becoming the gold standard for non-surgical skin rejuvenation—and for good reason.
At Mesglo Aesthetic Clinic London, we are proud to offer advanced polynucleotide therapies for the face, eyes, and scalp. In this article, we’ll explore what polynucleotides are, how they work, and why they’re the molecule everyone’s talking about in 2025.
What Are Polynucleotides?
Polynucleotides (PNs) are biopolymers composed of DNA and RNA fragments, often derived from salmon DNA due to its high biocompatibility with human tissue. In aesthetics, these fragments are used to stimulate deep skin regeneration by activating your body’s own healing and repair mechanisms.
Rather than filling or freezing the skin, polynucleotides work from the inside out, improving:
🔬 Cellular turnover and skin metabolism
🧬 DNA repair and fibroblast regeneration
💧 Hydration and dermal density
⚡ Collagen and elastin synthesis
🌿 Reduction in inflammation and oxidative stress
This makes them a powerful alternative to traditional injectables, particularly for patients seeking natural, long-term improvements in skin quality.
How Do Polynucleotides Rejuvenate the Skin?
When injected into the skin, polynucleotides trigger a biochemical cascade that kickstarts tissue regeneration. They work by:
- Activating Fibroblasts – Stimulating the cells responsible for producing collagen and elastin, leading to firmer, more elastic skin.
- Repairing Cellular Damage – Supporting natural DNA repair processes, especially in sun-damaged or ageing skin.
- Improving Hydration – Acting like a molecular sponge, polynucleotides retain water and improve skin hydration from within.
- Anti-Inflammatory Action – Calming skin conditions and preventing chronic inflammation that contributes to ageing.
The result is glowing, resilient, youthful skin—without the need for fillers, toxins, or downtime.
What Can Polynucleotides Treat?
Polynucleotide therapy is remarkably versatile and can be used across multiple treatment areas:
Face
✔️ Fine lines and wrinkles
✔️ Skin laxity and thinning
✔️ Dullness and uneven texture
✔️ Acne scarring and pigmentation
Under-Eyes (Lumi Eyes)
✔️ Dark circles
✔️ Crepey or thin skin
✔️ Puffiness and under-eye hollowness
Scalp
✔️ Hair thinning and loss
✔️ Poor scalp quality
✔️ Follicle repair post-shedding
This makes polynucleotides ideal for patients looking for a natural, holistic rejuvenation plan that supports skin health across multiple zones.
Polynucleotides vs. Fillers vs. PRP: A Comparison
| Treatment | Mechanism | Best For | Longevity | Risk Profile |
|---|---|---|---|---|
| Polynucleotides | Cellular regeneration & DNA repair | Skin quality, hydration, inflammation | 6–12 months | Low (natural, biocompatible) |
| Dermal Fillers | Volume replacement | Cheeks, lips, contouring | 6–18 months | Moderate (overfilling, migration) |
| PRP | Growth factors from your own blood | Mild rejuvenation, early hair loss | 3–6 months | Low (but variable efficacy) |
Polynucleotides stand out for their regenerative power and versatility, offering a science-backed, non-volumising alternative to more traditional aesthetic injectables.
Who Is It For?
Polynucleotide treatments are suitable for:
✔️ Individuals seeking natural skin improvement without artificial volume.
✔️ Patients with sensitive or damaged skin (e.g., post-acne, rosacea, post-laser).
✔️ Anyone experiencing early signs of ageing.
✔️ Clients who want to prevent skin decline before it starts.
✔️ Those looking to combine treatment with microneedling, exosomes, or RF therapy.
Whether you’re in your late 20s or well into your 50s, polynucleotides offer benefits at every stage of the skin health journey.
Treatment Process and What to Expect
1. Consultation
At Mesglo London, your journey begins with a full skin assessment to determine your eligibility and customise your treatment plan.
2. Application
- Polynucleotides are delivered via microinjection or mesotherapy, targeting areas of concern.
- Most sessions take just 30–45 minutes and are virtually painless with numbing cream.
3. Aftercare
- Mild redness and swelling may occur but resolve within 24–48 hours.
- You can return to normal activity immediately.
4. Results Timeline
- 1 Week: Improved hydration and glow.
- 4–6 Weeks: Increased firmness, reduced lines.
- 3 Months: Ongoing regeneration with peak results.
Most patients benefit from 3 sessions spaced 2–3 weeks apart, followed by maintenance every 6–9 months.
Are Polynucleotides Safe?
Yes—polynucleotides are one of the safest skin treatments available, with decades of use in regenerative medicine.
- Derived from high-purity, sterile DNA, they’re biocompatible and non-immunogenic.
- Suitable for all skin types, including sensitive or compromised skin.
- No risk of allergic reaction, migration, or overfilling.
Unlike fillers or botulinum toxin, which can change facial volume or movement, polynucleotides enhance what’s already yours—naturally and gradually.
Why Choose Mesglo London for Polynucleotide Skin Therapy?
At Mesglo, we’re known for our expertise in regenerative aesthetics and our commitment to personalised care. When it comes to polynucleotides, we offer:
🌟 Tailored treatment plans that combine polynucleotides with exosomes, microneedling, or RF for maximum benefit.
🌟 Skilled practitioners trained in precision techniques for eyes, face, and scalp.
🌟 Luxury clinical environment in London’s West End with a focus on subtle, natural results.
Our mission is to deliver true skin regeneration, not just superficial improvement—and polynucleotides are one of our most powerful tools.
Book Your Polynucleotide Consultation Today
Ready to experience the molecule everyone’s talking about? Book your consultation at Mesglo Aesthetic Clinic London and discover the power of skin regeneration from within.
📍 Mesglo Aesthetic Clinic London
Unit 4, 10 Portman Square, London W1H 6AZ, United Kingdom
🌍 https://mesglolondon.co.uk/
📅 Your skin’s future starts now—schedule your appointment today!