Polynucleotides Facial Treatment Marylebone, London | Advanced Skin Regeneration Treatment
Deep Skin Regeneration, Hydration & Lifting
Polynucleotide therapy is an advanced, scientifically backed skin bio-stimulation treatment that rejuvenates, hydrates, and strengthens the skin at a cellular level. Using highly purified polynucleotides derived from Salmon DNA, this treatment stimulates collagen and elastin production, offering a powerful lifting and hydrating effect without altering facial features. At Mesglo Clinic in Marylebone, London, we provide expert polynucleotide facial treatments to restore skin health, combat ageing, and enhance skin firmness with minimal downtime.
Excellent service! Rahena was very friendly and attentive to my needs. Results to my treatment were amazing! Highly recommend!
Rahena consistently provides a premium service - my lashes and brows always look immaculate afterwards and the tint lasts for weeks. Highly recommend!
I had a chemical brow lift treatment at Mesglo London, and the entire experience from consultation to treatment was a perfect 10/10. Rahena is incredibly professional and knowledgeable, making me feel completely at ease. I’d definitely recommend Mesglo London to anyone!
Had an amazing experience with my Exosome treatment! Rahena provided an excellent service, and the treatment itself was amazing. I’m already seeing great results and couldn’t be happier. Highly recommend!
Amazing Service!
Raheena is friendly, professional, and knowledgeable. She made me feel comfortable, listened to what I wanted, and gave me great advice. The treatment was smooth, and I love the results. Highly recommend!
Raheena is friendly, professional, and knowledgeable. She made me feel comfortable, listened to what I wanted, and gave me great advice. The treatment was smooth, and I love the results. Highly recommend!
I experienced such great service, felt understood and most of all have had a great outcome after having Exosomes. I will definitely come back, wouldn’t think of going anywhere else. Thank you Raheena you have definitely made my skin glow
I had my Botox with miss Rahena and it was the best Botox I have had. It has lasted so long and I will definitely be booking in for more treatments with her. I highly recommend her and her practice.
I would recommend Rahena for everything! Amazing service and results are perfect.
I had an amazing experience! Rahina was incredibly friendly, and the treatment was great. I felt genuinely cared for throughout my visit. Can’t wait for my next session
I had an amazing experience! Rahena was incredibly friendly, and the treatment was great. I felt genuinely cared for throughout my visit. Can’t wait for my next session
Polynucleotide Treatment Results
Treatment Overview
📍 Treatment Areas:
- Face
- Neck
- Décolletage
⏳ Procedure Time: 30–45 minutes
💉 Anaesthesia: Optional numbing cream
⏱️ Downtime: Minimal (mild swelling or redness may last up to 48 hours)
📆 Results Last: 6–12 months
🔄 Recommended Sessions: 4–6 sessions spaced 2–4 weeks apart for best results
Polynucleotide Treatment Price From £350
WHAT ARE POLYNUCLEOTIDES?
Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA. In aesthetic medicine, we use highly purified polynucleotides derived from Salmon DNA, which have been processed to remove all potential allergens while preserving their regenerative properties.
These polynucleotides contain:
- Nucleotides that support cellular repair and regeneration
- Phosphate groups that enhance cellular metabolism
- Deoxyribose sugars that provide structural support
- Nitrogenous bases that facilitate proper DNA function
Unlike many other treatments that simply add volume or temporarily mask signs of ageing, polynucleotides work at the cellular level to stimulate your skin’s natural regenerative processes, creating more sustainable and natural-looking results.
According to research published in the Journal of Clinical and Aesthetic Dermatology, polynucleotide treatments can increase skin hydration by up to 89% and improve elasticity by 27% after a series of treatments [1].
Benefits of Polynucleotide Facial Therapy
COMPREHENSIVE SKIN REJUVENATION
Benefit | Description |
|---|---|
Collagen stimulation | Increases production of new collagen fibers for improved firmness |
Elastin enhancement | Restores skin elasticity and resilience |
Cellular regeneration | Accelerates turnover of healthy skin cells |
Barrier restoration | Strengthens the skin’s protective barrier function |
Hydration optimization | Improves the skin’s ability to retain moisture |
ADVANCED ANTI-AGING EFFECTS
Benefit | Description |
|---|---|
Fine line reduction | Smooths superficial lines through improved hydration and structure |
Wrinkle improvement | Softens deeper wrinkles through collagen remodeling |
Texture refinement | Creates smoother, more even skin texture |
Tone correction | Reduces redness and evens skin tone |
Natural lifting | Provides subtle but noticeable improvement in facial contours |
PRACTICAL ADVANTAGES
Benefit | Description |
|---|---|
Minimal downtime | Return to normal activities within 24-48 hours |
Natural results | Enhancement that looks completely natural |
Progressive improvement | Results that continue to develop over time |
Complementary effects | Works synergistically with other treatments |
Preventative benefits | Helps prevent future signs of aging |
HOW POLYNUCLEOTIDE THERAPY WORKS
Polynucleotide therapy works through several sophisticated biological mechanisms to rejuvenate the skin:
Cellular Regeneration
Polynucleotides provide the building blocks necessary for DNA repair and cellular regeneration, helping to:
- Accelerate cell turnover for fresher, more youthful skin
- Support DNA repair in damaged skin cells
- Enhance cellular metabolism for improved function
- Optimize protein synthesis essential for skin structure
This cellular regeneration creates improvements that continue to develop over time as new, healthier cells replace older, damaged ones.
Extracellular Matrix Enhancement
The extracellular matrix provides structural support for your skin. Polynucleotides enhance this matrix by:
- Stimulating fibroblasts to produce new collagen and elastin
- Improving the organization of collagen fibers
- Enhancing glycosaminoglycan synthesis for better hydration
- Strengthening the connections between skin cells
A 2023 study in Dermatologic Surgery demonstrated that polynucleotide treatment increased collagen density by 32% after three months of treatment [2].
Deep Hydration Mechanism
Polynucleotides create deep, lasting hydration through:
- Increasing hyaluronic acid production within the skin
- Enhancing the skin’s ability to bind and retain water
- Creating a moisture reservoir in the dermis
- Improving the skin’s natural moisture barrier
This hydration mechanism is particularly effective because it works from within rather than simply adding moisture from the outside.
Anti-inflammatory Effects
Polynucleotides help calm and soothe the skin by:
- Reducing inflammatory cytokines
- Neutralizing free radicals that cause oxidative stress
- Modulating immune responses in the skin
- Accelerating healing processes
These anti-inflammatory effects make polynucleotide therapy suitable even for sensitive skin types and help create a healthier skin environment overall.
POLYNUCLEOTIDE TREATMENT RESULTS
Our polynucleotide facial therapy delivers transformative results through advanced cellular regeneration:
- Deep hydration – Significant improvement in skin moisture levels and retention
- Enhanced skin elasticity – Visible improvement in skin firmness and bounce
- Reduced fine lines – Softening of superficial lines and wrinkles
- Improved skin texture – Smoother, more refined skin surface
- Natural lifting effect – Subtle but noticeable improvement in facial contours
- Accelerated healing – Faster recovery from environmental damage and procedures
Results begin to appear within days of treatment, with continued improvement over 2-3 months as cellular regeneration progresses. The comprehensive rejuvenation typically lasts 6-12 months, with maintenance treatments recommended to sustain optimal results.
POLYNUCLEOTIDE THERAPY VS. OTHER TREATMENTS
Treatment | Primary Mechanism | Downtime | Results Duration | Best For |
|---|---|---|---|---|
Polynucleotide Therapy | Cellular regeneration and DNA repair | Minimal (24-48 hours) | 6-12 months | Comprehensive rejuvenation, hydration, and natural lifting |
Hyaluronic Acid Fillers | Volume replacement | Minimal | 6-18 months | Volume loss, deep wrinkles, contouring |
Botulinum Toxin | Muscle relaxation | None | 3-4 months | Dynamic wrinkles, expression lines |
Chemical Peels | Controlled skin injury and renewal | 3-14 days | 1-3 months | Surface texture, mild pigmentation |
Microneedling | Collagen induction through micro-injuries | 1-3 days | 4-6 weeks | Texture, mild scarring, general rejuvenation |
Laser Resurfacing | Controlled thermal injury and renewal | 5-14 days | 1-2 years | Significant sun damage, deeper wrinkles, texture |
What Skin Concerns Can Polynucleotides Address?
- ✔ Loss of firmness & elasticity – Lifts sagging areas for tighter skin
✔ Fine lines & wrinkles – Stimulates collagen for smoother texture
✔ Dehydrated, dull skin – Provides long-lasting moisture & glow
✔ Uneven skin tone – Enhances radiance & skin renewal
✔ Thin, fragile skin – Strengthens the skin barrier for improved resilience
What to Expect During Your Appointment
Your polynucleotide therapy journey at Mesglo London includes:
CONSULTATION
We begin with a thorough assessment of your skin concerns, medical history, and aesthetic goals to determine if polynucleotide therapy is right for you.
PREPARATION
- The treatment area is cleansed thoroughly
- Pre-treatment photographs may be taken
- Topical numbing cream is applied if desired (though most clients find the treatment comfortable with minimal discomfort)
TREATMENT
- Polynucleotide Application – The specialized polynucleotide solution is administered through microinjections into the treatment area
- Strategic Placement – Our expert practitioners use specific techniques to ensure optimal distribution and results
- Gentle Massage – A light massage may be performed to distribute the product evenly
AFTERCARE
- Detailed aftercare instructions are provided
- A specialized post-treatment skincare regimen may be recommended
- Follow-up appointments are scheduled to monitor your progress
Most clients experience only mild redness or swelling after treatment, which typically subsides within 24-48 hours. You can return to your normal activities immediately, though we recommend avoiding intense exercise, excessive heat, and direct sun exposure for 24-48 hours.
Who is This Treatment For?
Polynucleotide facial therapy is ideal for:
- Adults seeking comprehensive skin rejuvenation
- Those with early to moderate signs of aging
- Individuals looking for natural-looking results
- People with dehydrated or dull skin
- Those seeking to enhance and extend the results of other aesthetic procedures
- Individuals wanting improvement without significant downtime
- People with sensitive skin who may not tolerate more aggressive treatments
This treatment is not suitable for pregnant or breastfeeding women, those with active skin infections or inflammatory conditions, or individuals with certain autoimmune disorders.
Frequently Asked Questions
HOW DO POLYNUCLEOTIDES DIFFER FROM HYALURONIC ACID FILLERS?
While both treatments can improve skin hydration and appearance, they work very differently:
Polynucleotides work at the cellular level to stimulate your skin’s natural regenerative processes, including collagen and elastin production. They provide building blocks for DNA repair and cellular function, creating more natural and progressive results that improve over time.
Hyaluronic Acid Fillers physically add volume to specific areas by injecting a gel-like substance. They provide immediate results but don’t stimulate your skin’s natural regenerative processes to the same degree.
Research published in Aesthetic Plastic Surgery showed that polynucleotide treatments produced more natural-looking results with better long-term skin quality improvements compared to hyaluronic acid treatments.
HOW MANY TREATMENTS WILL I NEED?
For optimal results, we recommend:
- Initial Phase: Series of 4-6 treatments, spaced 2-4 weeks apart
- Maintenance: Follow-up treatments every 6-12 months
Your specific treatment plan will be customized based on your skin condition, age, and aesthetic goals. Some clients with more advanced signs of aging may benefit from additional initial treatments.
CAN I COMBINE POLYNUCLEOTIDE THERAPY WITH OTHER TREATMENTS?
Yes, polynucleotide therapy works synergistically with many other aesthetic treatments. In fact, combining treatments often produces superior results than either treatment alone. Popular combinations include:
- Polynucleotides + Anti-Wrinkle Treatments: Relaxes muscles while regenerating skin
- Polynucleotides + Exosome Therapy: Enhanced cellular communication and regeneration
- Polynucleotides + Chemical Brow Lift: Lifts brows while rejuvenating surrounding skin
We recommend spacing combined treatments appropriately, which we’ll discuss during your consultation.
ARE THERE ANY SIDE EFFECTS?
Polynucleotide therapy is generally very well-tolerated with minimal side effects. Potential temporary effects may include:
- Mild redness for 24-48 hours
- Slight swelling, typically resolving within 48 hours
- Temporary sensitivity
- Occasional small bruises at injection sites
Serious side effects are extremely rare. Our practitioners are highly trained in proper polynucleotide administration techniques to ensure your safety and comfort.
HOW QUICKLY WILL I SEE RESULTS?
Many clients notice an immediate improvement in skin hydration and luminosity after treatment. However, the most significant results develop over time:
- Days 1-7: Initial improvement in skin hydration and luminosity
- Weeks 2-4: Noticeable enhancement in skin texture and tone
- Months 1-3: Progressive improvement in fine lines, wrinkles, and overall skin quality
- Months 3-6: Continued structural improvements as collagen and elastin remodeling progresses
The regenerative nature of polynucleotide therapy means results continue to develop over time, with many clients reporting ongoing improvements for up to 3 months after completing their treatment series.
BOOK YOUR POLYNUCLEOTIDE FACIAL TREATMENT IN MARYLEBONE, LONDON TODAY
Experience the transformative effects of our advanced polynucleotide therapy at Mesglo Clinic in Marylebone, London. Our expert practitioners specialise in this cutting-edge treatment to deliver natural-looking, comprehensive rejuvenation.
📍 Clinic Location:
Mesglo Aesthetic Clinic Marylebone, London, Unit 4, 10 Portman Square, London, W1H 6AZ
📞 Call Us: 07830402077
📅 Contact Us: info@mesglolondon.co.uk