How is polynucleotide treatment different from dermal fillers?

Unlike dermal fillers that add volume by physically filling an area, polynucleotides work by stimulating your skin's own regenerative processes. They improve skin quality from within — increasing hydration, collagen production, and elasticity — rather than simply filling lines or adding volume. The results are more natural and progressive.

How many polynucleotide sessions do I need?

Most clients benefit from 2-3 sessions spaced 3-4 weeks apart for an initial course. Results continue to improve for up to 8 weeks after the final session. Maintenance treatments every 6-12 months are recommended to sustain the regenerative benefits.

Is polynucleotide treatment safe?

Yes, polynucleotide treatments have an excellent safety profile and have been used in aesthetic medicine for over 20 years. The purified DNA is highly biocompatible and biodegradable. Side effects are typically mild and temporary, including minor redness or swelling at injection sites that resolves within 24-48 hours.

Can polynucleotides be combined with other treatments?

Yes, polynucleotides combine exceptionally well with other regenerative treatments. Combining with exosome therapy amplifies the regenerative signal, while pairing with Profhilo addresses both tissue regeneration and deep hydration simultaneously. Microneedling can also be used to enhance polynucleotide absorption. Your practitioner will recommend the optimal combination for your skin goals.

Polynucleotide Face Treatment London - Skin Rejuvenation Marylebone

Polynucleotide therapy is one of our most effective regenerative skin treatments for skin laxity, dehydration, fine lines, and loss of elasticity. At Mesglo Aesthetic Clinic Marylebone, London, we use a bespoke injection protocol to stimulate fibroblast activity, collagen production, and deep tissue hydration, delivering progressive skin quality improvements with minimal downtime.

Price: From £300 | Duration: 45-60 minutes | Results: Progressive improvement over 4-8 weeks

How Polynucleotide Treatment Works

Polynucleotides are chains of nucleotides derived from purified DNA. When injected into the skin, they stimulate fibroblast proliferation, increase collagen and elastin synthesis, and provide intense hydration at the dermal level. The treatment also has powerful anti-inflammatory and antioxidant properties, making it ideal for skin rejuvenation and repair.

Benefits

Deep tissue regeneration at the cellular level
Intense, long-lasting hydration
Improved skin elasticity and firmness
Reduction in fine lines and wrinkles
Enhanced skin texture and luminosity
Anti-inflammatory and antioxidant effects

The Treatment Process

Comprehensive skin assessment and consultation
Cleansing and preparation of the treatment area
Strategic injection of polynucleotide solution
Post-treatment soothing and hydration
Aftercare instructions and follow-up scheduling

Frequently Asked Questions

How is polynucleotide treatment different from fillers?

Unlike fillers that add volume, polynucleotides work by stimulating your skin's own regenerative processes. They improve skin quality from within rather than simply filling lines or adding volume.

How many sessions do I need?

Most clients benefit from 2-3 sessions spaced 3-4 weeks apart, with maintenance treatments every 6-12 months for sustained results. Read our detailed guide: How Many Polynucleotide Sessions Do You Actually Need?

Is Polynucleotide Face Treatment Right for You?

Best suited for: Skin laxity, dehydration, loss of elasticity, fine lines, and dull complexion. Well-suited to clients who want progressive, natural-looking skin quality improvement rather than added volume.
Not suitable for: This treatment may not be suitable during pregnancy or breastfeeding, with active infection in the treatment area, or with known sensitivity to the product components. Suitability is confirmed at consultation.
Possible side effects: Possible side effects vary depending on individual response. Mild redness, small transient bumps at injection sites, or bruising for 24–48 hours is typical. Rahena will discuss your individual risk profile at consultation.
Consultation required: Rahena will assess suitability, treatment goals, medical history, and skin condition before recommending any treatment. How many polynucleotide sessions you need will be confirmed at your consultation.
Alternatives to consider: If volume restoration is your primary concern, dermal fillers or Profhilo may be more appropriate. For the most advanced regenerative approach, polynucleotides can be combined with exosome therapy.

Book your polynucleotide face treatment at Mesglo London.

Visit Our Marylebone Clinic

Mesglo London is located in the heart of Marylebone, W1G, London — one of the capital's most prestigious neighbourhoods. Our clinic is easily accessible from Baker Street, Bond Street, and Regent's Park Underground stations.

View Mesglo London on Google Maps for directions, opening hours, and patient reviews.

Compare Polynucleotide Face Treatment with Other Treatments

Not sure if Polynucleotide Face Treatment is the right choice for you? Use our interactive comparison tool to see how Polynucleotide Face Treatment compares with other treatments at Mesglo London. Compare prices, downtime, results timelines, and more side by side.

Compare Polynucleotide Face Treatment with alternatives

What Our Clients Say

Rated 5.0 / 5 from verified Google reviews.

Mesglo is hands down the best aesthetic clinic I've been to. Professional, clean, and the results speak for themselves. The polynucleotide treatment has transformed my skin texture.

— Jessica W., verified Google review

I finally found a clinic that delivers results I actually love. The attention to detail and personalised approach made all the difference. My skin has never looked better.

— Victoria S., verified Google review