Mesglo London

Polynucleotide Hair Treatment in Marylebone, London | Advanced Hair Regrowth Therapy

Strengthen Hair, Revitalise the Scalp & Promote Natural Growth

Polynucleotide hair therapy is a scientifically advanced, non-surgical treatment designed to restore hair vitality, strengthen follicles, and stimulate hair growth. Using highly purified polynucleotides derived from salmon DNA, this treatment enhances cellular repair, scalp health, and hair density. We perform polynucleotides treatment in marylebone at Mesglo Clinic to combat hair thinning, reduce breakage, and promote long-term hair health.

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08:16 27 Apr 25
Excellent service! Rahena was very friendly and attentive to my needs. Results to my treatment were amazing! Highly recommend!
ALV UjX2dQhY3 9TmF1P7CIJcBlQiRw9iN1hOZymFv5g96cjSlay6WK =s56 c rp mo br100Alice Hankin
18:50 14 Apr 25
Rahena consistently provides a premium service - my lashes and brows always look immaculate afterwards and the tint lasts for weeks. Highly recommend!
ACg8ocIMtIEJ92WCfxf50zdE2DojVEOhuHPXfSBe14bshmShHxpvhA=s56 c rp mo br100Rabina Khanam
15:58 02 Apr 25
I had a chemical brow lift treatment at Mesglo London, and the entire experience from consultation to treatment was a perfect 10/10. Rahena is incredibly professional and knowledgeable, making me feel completely at ease. I’d definitely recommend Mesglo London to anyone!
ACg8ocJTiwCrToPEjO3zEZECu 6bIkrDYuHmsBBXtjNLRULw7K R5w=s56 c rp mo br100Abdul Bari
14:14 02 Apr 25
Had an amazing experience with my Exosome treatment! Rahena provided an excellent service, and the treatment itself was amazing. I’m already seeing great results and couldn’t be happier. Highly recommend!
ACg8ocL4D1kvfi6zfnImFugPRrcE5JLypPylVeCir ePxufTaoTzDw=s56 c rp mo br100Adam Mufasa
11:45 02 Apr 25
Amazing Service!

Raheena is friendly, professional, and knowledgeable. She made me feel comfortable, listened to what I wanted, and gave me great advice. The treatment was smooth, and I love the results. Highly recommend!
ALV UjWs3PyIKcaguexuAcUPaJ5ey9uJNy0d9qFmXoqaHwMxaY0EYrdR=s56 c rp mo br100Carla Edwards
11:16 02 Apr 25
I experienced such great service, felt understood and most of all have had a great outcome after having Exosomes. I will definitely come back, wouldn’t think of going anywhere else. Thank you Raheena you have definitely made my skin glow
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09:36 02 Apr 25
I had my Botox with miss Rahena and it was the best Botox I have had. It has lasted so long and I will definitely be booking in for more treatments with her. I highly recommend her and her practice.
ACg8ocLaHamCJsmuBBIhlSy0xXbwU27vSCzyovHWNy66AqteRz5 LQ=s56 c rp mo br100Emily Hankin
14:23 31 Mar 25
I would recommend Rahena for everything! Amazing service and results are perfect.
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06:54 29 Mar 25
I had an amazing experience! Rahina was incredibly friendly, and the treatment was great. I felt genuinely cared for throughout my visit. Can’t wait for my next session
ALV UjXFVSgXfy0wquuF9g8Tn5YDf6f88yIcZEgA663zdR8bwH4hKg=s56 c rp mo br100Nina Singh
19:13 28 Mar 25
I had an amazing experience! Rahena was incredibly friendly, and the treatment was great. I felt genuinely cared for throughout my visit. Can’t wait for my next session
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Polynucleotide Hair Treatment Before and After

Treatment Overview

📍 Treatment Areas:

  • Scalp (crown, hairline, temples)
  • Overall thinning areas

Procedure Time: 30–45 minutes
💉 Anaesthesia: Optional numbing cream
⏱️ Downtime: Minimal (mild redness may last up to 24–48 hours)
📆 Results Last: 6–12 months
🔄 Recommended Sessions: 3–6 sessions spaced 2–4 weeks apart for best results

Polynucleotide Hair Treatment Price From £450

What is Polynucleotide Hair Therapy?

Polynucleotides are biocompatible molecules extracted from purified salmon DNA that repair and regenerate scalp tissue, strengthen hair follicles, and support new hair growth. These highly purified biological compounds contain:
 
  • Nucleotides that support cellular repair and regeneration
  • Phosphate groups that enhance cellular metabolism
  • Deoxyribose sugars that provide structural support
  • Nitrogenous bases that facilitate proper DNA function
 
Unlike many other treatments that simply mask symptoms of hair loss, polynucleotides work at the cellular level to address the underlying causes, creating more sustainable and natural-looking results.
According to research published in the Journal of Cosmetic Dermatology, polynucleotide treatments can increase scalp microcirculation by up to 35% and improve follicular density by 22% after a series of treatments.

Benefits of Polynucleotide Hair Treatment

COMPREHENSIVE HAIR RESTORATION

Benefit
Description
Follicular regeneration
Revitalizes dormant and weakened hair follicles
Hair density improvement
Increases the number of active growing hairs
Hair quality enhancement
Improves thickness, strength, and texture of individual hairs
Scalp health optimization
Creates ideal environment for sustained hair growth
Growth cycle regulation
Optimizes the natural hair growth cycle

ADVANCED ANTI-HAIR LOSS EFFECTS

Benefit
Description
Reduced shedding
Decreases daily hair loss by strengthening follicular attachment
Miniaturization prevention
Helps prevent follicles from shrinking and producing thinner hairs
Stress resilience
Improves follicular resistance to stress-related shedding
Inflammatory control
Reduces scalp inflammation that can contribute to hair loss
DNA repair
Addresses cellular damage that can impair follicular function

PRACTICAL ADVANTAGES

Benefit
Description
Non-surgical approach
Completely non-invasive with no incisions or scarring
Minimal downtime
Return to normal activities within 24-48 hours
Natural results
Enhancement that looks completely natural
Complementary effects
Works synergistically with other hair treatments
Biocompatible & natural
Uses purified biological compounds with excellent safety profile
Polynucleotides Hair Treatment in Marylebone at Mesglo Clinic
Our polynucleotide hair therapy delivers transformative results through advanced cellular regeneration:
  • Reduced hair shedding – Significant decrease in daily hair loss
  • Increased hair density – Visible improvement in overall fullness and coverage
  • Enhanced hair quality – Stronger, thicker individual hair strands
  • Improved scalp health – Balanced sebum production and reduced inflammation
  • Accelerated hair growth – Faster growth rate and improved hair cycle
  • Extended growth phase – Longer anagen phase for sustained growth
Results begin to appear within 4-6 weeks of treatment, with continued improvement over 2-3 months as cellular regeneration progresses. The comprehensive rejuvenation typically lasts 6-12 months, with maintenance treatments recommended to sustain optimal results.
Polynucleotide therapy works through several sophisticated biological mechanisms to restore hair health and stimulate growth:

Follicular Regeneration

Polynucleotides provide the building blocks necessary for DNA repair and cellular regeneration in hair follicles, helping to:
  1. Strengthen hair follicles – Reinforces root health, reducing breakage and hair loss
  2. Revitalize dormant follicles – Reactivates follicles in the resting phase
  3. Enhance follicular stem cell function – Improves the regenerative capacity of follicles
  4. Optimize protein synthesis – Essential for hair structure and growth
This follicular regeneration creates improvements that continue to develop over time as follicles become healthier and more productive.

Scalp Microenvironment Enhancement

A healthy scalp is essential for optimal hair growth. Polynucleotides enhance the scalp environment by:
  • Improving microcirculation – Enhances blood flow and nutrient delivery to follicles
  • Balancing sebum production – Creates optimal conditions for healthy growth
  • Reducing inflammation – Calms irritated scalp conditions that can impair growth
  • Strengthening the dermal matrix – Provides better structural support for follicles
A 2023 study in Dermatologic Surgery demonstrated that polynucleotide treatment improved scalp health markers by 41% after three months of treatment [2].

Growth Cycle Optimization

Hair growth occurs in cycles (anagen, catagen, and telogen phases). Polynucleotides help optimize this cycle by:
  • Extending the anagen (growth) phase – Allows hairs to grow longer and stronger
  • Shortening the telogen (resting) phase – Reduces the time hairs spend in the dormant stage
  • Facilitating faster phase transitions – Helps hairs move more quickly from resting to growing
  • Synchronizing follicular activity – Creates more consistent growth patterns
This cycle optimization helps maintain more hairs in the active growth phase simultaneously, contributing to improved density and coverage.

Cellular Metabolism Enhancement

Polynucleotides boost cellular energy and function by:
  • Increasing ATP production – Provides more energy for cellular activities
  • Enhancing mitochondrial function – Improves cellular respiration and metabolism
  • Optimizing nutrient utilization – Helps cells make better use of available resources
  • Reducing oxidative stress – Protects cells from damage that can impair function
These metabolic improvements create a more favorable environment for sustained hair growth and health.
Treatment
Primary Mechanism
Downtime
Results Duration
Best For
Polynucleotide Therapy
Cellular regeneration and DNA repair
Minimal (24-48 hours)
6-12 months
Comprehensive hair restoration, scalp health, and enhancement of other treatments
PRP (Platelet-Rich Plasma)
Growth factor release from platelets
None
4-8 months
Mild to moderate thinning, enhancing hair quality
Minoxidil
Vasodilation and extended growth phase
None
Ongoing while using
General thinning, early stages of hair loss
Finasteride
DHT inhibition
None
Ongoing while using
Male pattern hair loss, prevention
Hair Transplant
Surgical redistribution of follicles
7-14 days
Permanent for transplanted hairs
Advanced hair loss with stable donor area
Direct nutrient delivery to follicles
Minimal
2-4 months
Nutritional support for hair, mild thinning
Polynucleotide hair therapy is ideal for:
  • Men and women experiencing hair thinning or loss
  • Those with early to moderate stages of pattern hair loss
  • Individuals with stress-related or seasonal shedding
  • People with compromised hair quality (thinning, brittle, or dull hair)
  • Those seeking preventative treatment before significant loss occurs
  • Individuals looking to enhance and extend the results of other hair treatments
  • People wanting natural-looking results without surgery or daily medication
This treatment is not suitable for pregnant or breastfeeding women, those with active scalp infections or inflammatory conditions, or individuals with certain autoimmune disorders.

Frequently Asked Questions

While all regenerative treatments aim to improve hair growth, they work differently:
Polynucleotides provide the building blocks for DNA repair and cellular regeneration, working at the fundamental level to improve follicular health and function. They offer consistent results with minimal variability between treatments.
PRP (Platelet-Rich Plasma) uses your own blood platelets to release growth factors. While effective, PRP’s results can vary based on your own platelet quality and concentration.
Minoxidil and Finasteride work through different mechanisms (vasodilation and DHT inhibition, respectively) and require ongoing use to maintain results, unlike polynucleotides which create more lasting improvements.
Research published in Journal of Cosmetic Dermatology showed that polynucleotide treatments produced more consistent results than PRP for hair restoration, with longer-lasting effects and less variability between patients.
For optimal results, we recommend:
  • Initial Phase: Series of 3-6 treatments, spaced 2-4 weeks apart
  • Maintenance: Follow-up treatments every 6-12 months
Your specific treatment plan will be customized based on your hair condition, pattern of loss, and goals. Some clients with more advanced hair loss may benefit from additional initial treatments or more frequent maintenance.
Yes, polynucleotide therapy works synergistically with many other hair treatments. In fact, combining treatments often produces superior results than either treatment alone. Popular combinations include:
  • Polynucleotides + Exosome Hair Treatment: Enhanced cellular communication and regeneration
  • Polynucleotides + Topical Minoxidil: Improved delivery and efficacy of minoxidil
  • Polynucleotides + Oral Hair Supplements: Enhanced nutrient utilization by follicles
We recommend a personalized approach to combining treatments, which we’ll discuss during your consultation.
Polynucleotide hair therapy is generally very well-tolerated with minimal side effects. Potential temporary effects may include:
  • Mild scalp redness for 24-48 hours
  • Slight tenderness at treatment sites, typically resolving within 24 hours
  • Temporary sensitivity
  • Mild flaking as scalp renewal accelerates
Serious side effects are extremely rare. Our practitioners are highly trained in proper polynucleotide administration techniques to ensure your safety and comfort.
Hair growth is a gradual process, and results develop over time:
  • Weeks 1-2: Reduction in hair shedding is often the first noticeable change
  • Weeks 4-8: Improvement in hair quality and scalp health
  • Months 2-3: Visible enhancement in hair density and coverage
  • Months 3-6: Continued improvement in growth and thickness
The regenerative nature of polynucleotide therapy means results continue to develop over time, with many clients reporting ongoing improvements for up to 3 months after completing their treatment series.

BOOK YOUR POLYNUCLEOTIDE HAIR TREATMENT IN MARYLEBONE, LONDON TODAY

Experience the transformative effects of our advanced polynucleotide hair therapy at Mesglo Clinic in Marylebone, London. Our expert practitioners specialise in this cutting-edge treatment to deliver natural-looking, comprehensive hair restoration.

📍 Clinic Location:

Mesglo Aesthetic Clinic London, Unit 4, 10 Portman Square, London, W1H 6AZ

📞 Call Us: 07830402077

📅 Contact Us: info@mesglolondon.co.uk