Does Profhilo add volume like fillers?

No. Profhilo does not add visible volume. It spreads through the tissue and stimulates collagen and elastin production, improving skin firmness and quality. If you want to add volume to specific areas, dermal fillers are the appropriate treatment.

How long does Profhilo last compared to fillers?

Profhilo results typically last 6–9 months. Dermal fillers generally last 12–18 months depending on the product and area treated. Profhilo requires two initial sessions four weeks apart, whereas fillers usually require only one session.

Is Profhilo better than fillers for anti-ageing?

They address different aspects of ageing. Profhilo is better for improving skin quality, firmness, and glow. Fillers are better for restoring lost volume and structural definition. For comprehensive anti-ageing, a combination of both is often the most effective approach.

Can Profhilo be used under the eyes?

Profhilo is not typically used directly under the eyes due to the risk of swelling in this delicate area. For under-eye concerns, specialist treatments such as Lumi Eyes (polynucleotide eye treatment) or carefully placed tear trough filler are more appropriate.

Which is more painful, Profhilo or fillers?

Both treatments involve injections and topical anaesthetic is applied before both procedures. Profhilo uses fewer injection points (5 per side) but the volume per point is higher. Most patients find both treatments well-tolerated.

Profhilo vs Hyaluronic Acid Fillers: What's the Difference?

Written by Rahena, Level 7 Aesthetic Practitioner | Mesglo London

Profhilo and hyaluronic acid dermal fillers are both injectable treatments that use hyaluronic acid as their active ingredient. This shared foundation often causes confusion — patients frequently ask whether they are the same thing, or whether one can replace the other. The answer is no: they are fundamentally different products that work in different ways and produce different results. Understanding this distinction is essential to making informed aesthetic decisions.

What Is Profhilo?

Profhilo is a bio-remodelling treatment that contains one of the highest concentrations of pure hyaluronic acid available in any injectable product — 64mg in a 2ml syringe. Unlike dermal fillers, Profhilo is not cross-linked. This means it spreads through the tissue rather than staying in one place, stimulating the production of collagen and elastin across a wide area.

The treatment is administered at five specific anatomical points on each side of the face (the BAP technique), allowing the product to diffuse evenly and remodel the skin from within. Profhilo does not add volume; it improves the quality and firmness of the skin itself.

What Are Hyaluronic Acid Dermal Fillers?

Hyaluronic acid dermal fillers are cross-linked products — the HA molecules are chemically bonded together to create a gel of varying thickness and cohesivity. This cross-linking gives fillers their structural properties: they stay where they are injected, providing volume, definition, and lift.

Different filler products are designed for different purposes: soft, fluid fillers for lips and fine lines; firmer, more cohesive fillers for cheeks, jawline, and chin definition. The choice of product and injection technique determines the result.

Profhilo vs Dermal Fillers: A Direct Comparison

The key distinction is purpose: Profhilo improves skin quality; dermal fillers restore or add volume. A patient with good skin quality but significant volume loss in the cheeks needs fillers, not Profhilo. A patient with good facial structure but dull, lax skin needs Profhilo, not fillers. Many patients benefit from both.

Feature	Profhilo	Dermal Fillers
HA type	Non-cross-linked, pure HA	Cross-linked HA gel
Primary effect	Skin quality, firmness, glow	Volume, structure, definition
Spreads through tissue	Yes	No — stays where injected
Stimulates collagen/elastin	Yes	Minimal
Adds visible volume	No	Yes
Injection points	5 per side (BAP technique)	Targeted to specific areas
Sessions needed	2 sessions, 4 weeks apart	1–2 sessions
Duration	6–9 months	12–18 months
Price from	£350	£250

Who Is the Ideal Candidate for Each?

Profhilo is ideal for patients aged 30 and above who notice that their skin has lost its firmness, glow, and elasticity. It is particularly effective for the face, neck, and décolletage, and produces a subtle but significant improvement in overall skin quality.

Dermal fillers are ideal for patients who have experienced volume loss in specific areas — sunken cheeks, flattened lips, a receding chin, or deep nasolabial folds — and want to restore a more youthful facial structure.

Can You Have Profhilo and Dermal Fillers Together?

Yes — combining Profhilo and dermal fillers is one of the most effective approaches to comprehensive facial rejuvenation. Profhilo improves the overall quality and firmness of the skin, while fillers address specific structural concerns. The two treatments complement each other beautifully.

At Mesglo London, we often recommend a combination approach for patients seeking a natural, refreshed result without surgery. Your practitioner will design a personalised treatment plan based on your facial anatomy and aesthetic goals.

Conclusion

Profhilo and hyaluronic acid dermal fillers are both outstanding treatments, but they are not interchangeable. Profhilo is a skin quality treatment that improves firmness, hydration, and radiance. Dermal fillers are structural treatments that restore volume and definition. Understanding which you need — or whether you need both — is the starting point for any effective aesthetic programme. At Mesglo London, our practitioners take the time to assess your skin and facial anatomy thoroughly before recommending any treatment. Book a consultation at our Marylebone clinic to discover the most appropriate approach for your goals.

Frequently Asked Questions

Does Profhilo add volume like fillers?: No. Profhilo does not add visible volume. It spreads through the tissue and stimulates collagen and elastin production, improving skin firmness and quality. If you want to add volume to specific areas, dermal fillers are the appropriate treatment.
How long does Profhilo last compared to fillers?: Profhilo results typically last 6–9 months. Dermal fillers generally last 12–18 months depending on the product and area treated. Profhilo requires two initial sessions four weeks apart, whereas fillers usually require only one session.
Is Profhilo better than fillers for anti-ageing?: They address different aspects of ageing. Profhilo is better for improving skin quality, firmness, and glow. Fillers are better for restoring lost volume and structural definition. For comprehensive anti-ageing, a combination of both is often the most effective approach.
Can Profhilo be used under the eyes?: Profhilo is not typically used directly under the eyes due to the risk of swelling in this delicate area. For under-eye concerns, specialist treatments such as Lumi Eyes (polynucleotide eye treatment) or carefully placed tear trough filler are more appropriate.
Which is more painful, Profhilo or fillers?: Both treatments involve injections and topical anaesthetic is applied before both procedures. Profhilo uses fewer injection points (5 per side) but the volume per point is higher. Most patients find both treatments well-tolerated.